The strategy of cells to deal with the accumulation of misfolded proteins is identified


Proteins that appear in Schizosaccharomyces pombe cells when exposed to high temperatures. Credit: Margarita Cabrera

A new article by the Oxidative Stress and Cell Cycle research group at UPF identifies the main strategy of cells to deal with the accumulation of misfolded proteins. In the paper, published today in the journal Cell Reports, the Schizosaccharomyces pombe yeast model has been used to investigate the protein quality control process. The study was led by Elena Hidalgo, and postdoctoral researchers Margarita Cabrera and Susanna Boronat are its first authors.

Proteins are made up of chains of amino acids and during their formation they must fold to acquire an appropriate shape enabling them to perform their functions. However, when cells are subjected to stress or harm, such as high temperatures, some of the proteins may not fold properly. In this study, the…



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