New insight as to how cells maintain their identity


Credit: University of Copenhagen

In the body’s cells, some proteins are of vital importance as to which genes are active or turned off. Now, researchers from the University of Copenhagen and the Memorial Sloan Kettering Cancer Center have discovered which proteins are necessary in order to maintain the proper genetic regulation.

All of the more than 200 different cell types in our body contain the same DNA. Which of those genes that are expressed determine each cell type. Therefore, it is essential that the activity of the genes is controlled with great precision.
Thus, a stem cell may develop into anything from a skin to a bone cell, depending on which parts of the genome are expressed.
The researchers in Professor Kristian Helin’s research group have for several years worked to understand the mechanisms that control whether a gene is active or inactive. This research is…



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